Publications 论文
1 Equal contribution · † Corresponding author 1 共同第一作者 · † 通讯作者
Preprints 预印本 16
- , Asymptotic properties of the Bingham distribution in arbitrary dimensions, arXiv:2609.07121. [arXiv]
- , First-Order Optimization under Uniform Nondegeneracy: Geometry, Computation, and Information, arXiv:2609.06946. [arXiv]
- , Computing stable configurations of confined smectic liquid crystals with a deep variational framework, arXiv:2609.03389. [arXiv]
- , Subspace curvature-scaling high-index saddle dynamics for accelerating ill-conditioned saddle point searches, arXiv:2607.03030. [arXiv]
- , A functional high-index saddle dynamics method for constructing control landscapes of non-convex elliptic optimal control problems, arXiv:2512.00732. [arXiv]
- , Deciphering interaction syntax via decoupling intrinsic lineages and niche pressure, bioRxiv 2026.05.18.725889. [DOI]
- , A Geometry-Adaptive Deep Variational Framework for Phase Discovery in the Landau-Brazovskii Model, arXiv:2603.05161. [arXiv]
- , A Landau-de Gennes Type Theory for Cholesteric-Helical Smectic-Smectic C* Liquid Crystal Phase Transitions, arXiv:2601.12653. [arXiv]
- , Numerical analysis of spatiotemporal high-index saddle dynamics for finding multiple solutions of semilinear elliptic problems, arXiv:2601.08188. [arXiv]
- , Sloppiness and Action Constraint in Cell State Transitions: Are Single Cells Sloppy?, bioRxiv 2025.12.31.697145. [DOI]
- , Nullspace-preserving high-index saddle dynamics method for degenerate multiple solution problems, arXiv:2510.24292. [arXiv]
- , SPIKE: Stable Physics-Informed Kernel Evolution Method for Solving Hyperbolic Conservation Laws, arXiv:2510.18266. [arXiv]
- , A Stochastic Algorithm for Searching Saddle Points with Convergence Guarantee, arXiv:2510.14144. [arXiv]
- , A nonlocal high-index saddle dynamics for nonlocal Allen-Cahn equation and application, submitted.
Published / Accepted 已发表 / 接受 109
- Accepted 已接受, Simulation-free Unbalanced Dynamic Optimal Transport with General Growth Penalty, accepted by NeurIPS 2026. [arXiv]
- Accepted 已接受, From molecular model to tensor model of nematic liquid crystals through entropy decomposition, accepted by SIAM J. Appl. Math. [arXiv]
- Accepted 已接受, Convergence of high-index saddle dynamics for degenerate saddle points on critical manifolds, accepted by SIAM J. Numer. Anal. [arXiv]
- Accepted 已接受, SaddleScape V1.0: A Python Package for Constructing Solution Landscapes via High-index Saddle Dynamics, accepted by Journal of Computational Mathematics. [arXiv]
- Accepted 已接受, A Derivative-Free Saddle-search Algorithm With Linear Convergence Rate, accepted by SIAM J. Sci. Comput. [arXiv]
- , Beyond Continuity: Simulation-free Reconstruction of Discrete Branching Dynamics from Single-cell Snapshots, ICML (2026). [arXiv]
- Highlight, Hierarchical and ultrametric barriers in the energy landscape of jammed granular matter, Physical Review Letters, 136, 198202 (2026). [DOI]
- , Design principles for robust multistability in coupled feedforward-feedback regulatory circuits, npj Syst. Biol. Appl. 12, 102 (2026). [DOI]
- , Efficient co-programming of intercellular mechanics and signaling for complex developmental patterns, Cell Reports Physical Science 7, 103344 (2026). [DOI]
- Highlight, Neural Network-based High-index Saddle Dynamics Method for Searching Saddle Points and Solution Landscape, SIAM J. Sci. Comput. 48(4), C916-C940 (2026). [DOI]
- Highlight, Numerical analysis for saddle dynamics of some semilinear elliptic problems, SIAM J. Numer. Anal. 64(3), 755-778 (2026). [DOI]
- Highlight, Analyzing the nematic liquid crystal droplet with an improved diffuse-interface Landau-de Gennes model, SIAM J. Appl. Math. 86(3), 919-944 (2026). [DOI]
- Highlight, Constructing a holistic map of cell fate decision by hyper solution landscape, Cell Systems, 17, 101562 (2026). [DOI]
- Highlight, Geometric Quantification of Cell Phenotype Transition Manifolds with Information Geometry, Cell Systems, 17, 101564 (2026). [DOI]
- , Exploring transition pathways in the Landau-Brazovskii model, Physical Review Research, 8, 013196 (2026). [DOI]
- Highlight, Unlocking Hidden Topological Multistability via Biphasic Correlated Order Evolution, Physical Review Letters, 136, 068101 (2026). [DOI]
- , Neural network-based tensor models for liquid crystals with molecular-level information, Phys. Rev. E, 113, 015401 (2026). [DOI]
- , Solution landscape of reaction-diffusion systems reveals a nonlinear mechanism and spatial robustness of pattern formation, Fundamental Research 6(4), 2137-2148 (2026). [DOI]
- Highlight, Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates, Nature Communications, 16, 9823 (2025). [DOI]
- Highlight, Improved high-index saddle dynamics for finding saddle points and solution landscape, SIAM J. Numer. Anal., 63(4), 1757-1775 (2025). [DOI]
- Highlight, A diffuse-interface Landau-de Gennes model for free-boundary nematic liquid crystals, SIAM J. Math. Anal. 57(4), 4358-4395 (2025). [DOI]
- , pETNNs: Partial Evolutionary Tensor Neural Networks for Solving Time-dependent Partial Differential Equations, CSIAM Transactions on Applied Mathematics, 6(4), 862-891 (2025). [DOI]
- , Construction and analysis for Adams explicit discretization of high-index saddle dynamics, CSIAM Transactions on Applied Mathematics, 6(3), 625-650 (2025). [DOI]
- , Positional BMP signaling orchestrates villus length in the small intestine, Nature Communications, 16, 5461 (2025). [DOI]
- , Solution landscape of droplet on rough surfaces: wetting transition and directional transport, Soft Matter, 21, 2729-2737 (2025). [DOI]
- , Construction and analysis for orthonormalized Runge-Kutta schemes of high-index saddle dynamics, Communications in Nonlinear Science and Numerical Simulation, 145, 108731 (2025). [DOI]
- Highlight, A Modified Landau-de Gennes Theory for Smectic Liquid Crystals: Phase Transitions and Structural Transitions, SIAM J. Appl. Math., 85(2), 821-847 (2025). [DOI]
- , Accelerated high-index saddle dynamics method for searching high-index saddle points, Journal of Scientific Computing, 102:31 (2025). [DOI]
- , The DNA methylation–demethylation balance prevents development of multiple megaspore mother cells in Arabidopsis, The Plant Cell, koaf023 (2025). [DOI]
- Highlight, Mathematical Modeling and Solution Landscape Reveal Cancer Progression Dynamics in Tumor Ecological Microenvironment, SIAM J. Appl. Math., 85(1), 50-77 (2025). [DOI]
- , Understanding high-index saddle dynamics via numerical analysis, Comm Math Sci., 23(2), 541-560 (2025). [DOI]
- , Nucleation and phase transition of decagonal quasicrystals, J. Chem. Phys., 161, 164503 (2024). [DOI]
- , Representing crystal potential energy surfaces via a stationary-point network, Acta Materialia, 281, 120403 (2024). [DOI]
- , Neural Quantile Optimization for Edge-Cloud Computing, Computer Networks, 253, 110713 (2024). [DOI]
- , scPLAN: A hierarchical computational framework for single transcriptomics data annotation, integration and cell-type label refinement, Briefings in Bioinformatics, 25.4 (2024). [DOI]
- , Semi-implicit method of high-index saddle dynamics and application to construct solution landscape, Numerical Methods for Partial Differential Equations, e23123 (2024). [DOI]
- Highlight, Multistability for Nematic Liquid Crystals in Cuboids with Degenerate Planar Boundary Conditions, SIAM J. Appl. Math., 84 (2), 756-781 (2024). [DOI]
- , Probabilistic Error Estimate for Numerical Discretization of High-Index Saddle Dynamics with Inaccurate Models, Ann. Appl. Math., 40(1), 1-20 (2024). [DOI]
- Highlight, Revealing Excited States of Rotational Bose-Einstein Condensates, The Innovation, 5(1), 100546 (2024). [DOI]
- , A Reduced Landau-de Gennes Study for Nematic Equilibria in Three-Dimensional Prisms, IMA Journal of Applied Mathematics, hxad031 (2023). [DOI]
- , A Logic-incorporated Gene Regulatory Network Deciphers Principles in Cell Fate Decisions, eLife 12:RP88742 (2023). [DOI]
- , Error estimate for semi-implicit method of sphere-constrained high-index saddle dynamics, Chinese Annals of Mathematics, Series B, 44(5), 765–780 (2023). [DOI]
- , Construction of solution landscapes for complex systems, Mathematica Numerica Sinica, 45(3), 267-283 (2023). [DOI]
- , A model-free shrinking-dimer saddle dynamics for finding saddle point and solution landscape, Japan Journal of Industrial and Applied Mathematics (2023). [DOI]
- Highlight, Spectral Deferred Correction Method for Landau-Brazovskii Model with Convex Splitting Technique, Journal of Computational Physics, 491 (2023) 112348. [DOI]
- , Discretization and index-robust error analysis for constrained high-index saddle dynamics on high-dimensional sphere, Science China Mathematics (2023). [DOI]
- , Hierarchies of Critical Points of a Landau-de Gennes Free Energy on Three-Dimensional Cuboids, Nonlinearity, 36, 2631 (2023). [DOI]
- , Energy landscape analysis for two-phase multi-component NVT flash systems by using ETD type high-index saddle dynamics, Journal of Computational Physics, 477, 111916 (2023).
- , MorphoSim: An efficient and scalable phase-field framework for accurately simulating multicellular morphologies, npj Systems Biology and Applications, (2023) 9:6. [DOI]
- , Comparison between phase-field model and coarse-grained model for characterizing cell-resolved morphological and mechanical properties in a multicellular system, Communications in Nonlinear Science and Numerical Simulation, 117, 106966 (2023). [DOI]
- , Mathematical and numerical analysis to shrinking-dimer saddle dynamics with local Lipschitz conditions, CSIAM Trans. Appl. Math., 4(1), 157-176 (2023). [DOI]
- Highlight, Error estimates for Euler discretization of high-index saddle dynamics, SIAM J. Numer. Anal., 60(5), 2925-2944 (2022). [DOI]
- Highlight, Convergence analysis of discrete high-index saddle dynamics, SIAM J. Numer. Anal., 60(5), 2731-2750 (2022). [DOI]
- Highlight, Nematic liquid crystals in a rectangular confinement: solution landscape and bifurcation, SIAM J. Appl. Math.82(5), 1808-1828 (2022). [DOI]
- Highlight, Network design principle for robust oscillatory behaviors with respect to biological noise, eLife, 11:e76188 (2022). [DOI]
- , Transition pathways in Cylinder-Gyroid interface, Commun. Comput. Phys., 32, 810-828 (2022). [DOI]
- Highlight, Computing solution landscape of nonlinear space-fractional problems via fast approximation algorithm, Journal of Computational Physics, 468, 111513 (2022). [DOI]
- Highlight, Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis, Science Advances, 8, eabn0368 (2022). [DOI]
- , Elastic anisotropy in the reduced Landau-de Gennes model for square domains, Proceedings of the Royal Society A, 478:20210966 (2022). [DOI]
- , The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation, iScience, 25, 104358 (2022). [DOI]
- , Chen*. Defect patterns of two-dimensional nematic liquid crystals in confinement, Physical Review E, 105, 044704 (2022). [DOI]
- , Constrained high-index saddle dynamics for the solution landscape with equality constraints, Journal of Scientific Computing, 91:62 (2022). [DOI]
- Highlight, Computable early Caenorhabditis elegans embryo with a phase field model, PLOS Computational Biology 18(1): e1009755 (2022). [DOI]
- Highlight, Solution Landscape of the Onsager Model Identifies Non-axisymmetric Critical Points, Physica D: Nonlinear Phenomena,430, 133081 (2022). [DOI]
- Highlight, Transition pathways connecting crystals and quasicrystals, Proceedings of the National Academy of Sciences, 118 (49), e2106230118 (2021). [DOI]
- , Construction of a Minimum Energy Path for the VT Flash Model by the String Method Coupled with the Exponential Time Differencing Scheme, Commun. Comput. Phys., 30, 1529-1544 (2021). [Link]
- , Solution Landscapes of the Simplified Ericksen-Leslie Model and its Comparison with the Reduced Landau-de Gennes Model, Proceedings of the Royal Society A, 477:20210458 (2021). [DOI]
- Highlight
- , Solution landscapes of the diblock copolymer-homopolymer model under two-dimensional confinement, Physical Review E, 104, 014505 (2021). [DOI]
- , Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin, iScience, 24, 102732 (2021). [DOI]
- , A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy, Molecular Plant, 14, 949–962 (2021). [DOI]
- Highlight, Solution landscape of a reduced Landau--de Gennes model on a hexagon, Nonlinearity, 34, 2048-2069 (2021). [DOI]
- , Numerical discretization of variational phase field model for phase transitions in ferroelectric thin films, Commun. Comput. Phys., 29, 729-746 (2021). [Link]
- , Global optimization-based dimer method for finding saddle points, Discrete Contin. Dyn. Syst. Ser. B 26(1): 741-753 (2021). [DOI]
- Highlight, Searching the solution landscape by generalized high-index saddle dynamics, Sci. China Math. 64, 1801–1816 (2021). [DOI]
- , Tuning cell motility via cell tension with a mechanochemical cell migration model, Biophysical Journal, 118, 2894–2904 (2020). [DOI]
- Highlight, A Reduced Study for Nematic Equilibria on Two-Dimensional Polygons, SIAM J. Appl. Math., 80(4), 1678–1703 (2020). [DOI]
- Highlight, Variational Phase Field Formulations of Polarization and Phase Transition in Ferroelectric Thin Films, SIAM J. Appl. Math., 80(3), 1590–1606 (2020). [DOI]
- Highlight, Construction of a pathway map on a complicated energy landscape, Physical Review Letters 124, 090601 (2020). [Link]
- , Noise control and utility: from gene regulatory network to spatial patterning, Sci. China Math 63, 425–440 (2020). [DOI]
- , Pathways connecting two opposed bilayers with a fusion pore: A molecularly-informed phase field approach, Soft Matter, 2020, 16, 366-374. [DOI]
- Highlight, High-index Optimization-based Shrinking Dimer Method for Finding High-Index Saddle Points, SIAM J. Sci. Comput., 41 (6), A3576-A3595. 2019. [Link]
- Highlight, Network Topologies That Can Achieve Dual Function of Adaptation and Noise Attenuation, Cell Systems 9, 1–15, 2019. [DOI]
- , Transition Pathways between Defect Patterns in Confined Nematic Liquid Crystals, J. Comput. Phys. 396 (2019) 1–11. [DOI]
- , Landscape reveals critical network structures for sharpening gene expression boundaries, BMC Systems Biology 12:67, 2018. [DOI]
- , Modeling craniofacial development reveals spatiotemporal constraints on robust patterning of the mandibular arch, PLoS Comput Biol 14(11): e1006569, 2018. [Link]
- , Phase Field Simulation of Critical Nuclei and Minimum Energy Paths of Cu/Mn/Ni Precipitates in Fe-Cu-Mn (Ni) Alloys, Journal of Nuclear Materials 507, 59-67, 2018. [DOI]
- , Nanog induced intermediate state in regulating stem cell differentiation and reprogramming, BMC Systems Biology 12:22, 2018. [DOI]
- Highlight, Feedback from Lateral Organs Controls Shoot Apical Meristem Growth by Modulating Auxin Transport, Developmental Cell, 44, 204-216, 2018. [DOI]
- , Finding Non-Classical Critical Nuclei and Minimum Energy Path of Cu Precipitates in Fe-Cu Alloys, Modelling Simul. Mater. Sci. Eng. 25 085006, 2017.
- , Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts, Development, 144, 2153-2164, 2017. [Link]
- , Exploring the inhibition effect of membrane tension on cell polarization, PLoS Comput Biol 13(1): e1005354. doi:10.1371/ journal.pcbi.1005354, 2017. [Link]
- , Recent Developments in Computational Modeling of Nucleation in Phase Transformations, npj Computational Materials (2016) 2, 16003.
- Highlight, Optimization-based Shrinking Dimer Method for Finding Transition States, SIAM J. Sci. Comput. 38:1, A528-A544, 2016.
- , Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline, Developmental Cell 35, 405-417, 2015.
- , Semi-adaptive response and noise attenuation in bone morphogenetic protein signalling, J. R. Soc. Interface 12: 20150258, 2015.
- , Finding Critical Nuclei in Phase Transformations by Shrinking Dimer Dynamics and its Variants, Commun. Comput. Phys., 16, pp. 781-798, 2014.
- , Non-classical nuclei and growth kinetics of Cr precipitates in FeCr alloys during aging, Modelling Simul. Mater. Sci. Eng., 22, 025002, 2014.
- , Array-representation Integration Factor Method for High-dimensional Systems, J. Comput. Phys., 258, 585-600, 2014.
- Highlight, Noise Drives Sharpening of Gene Expression Boundaries in the Zebrafish Hindbrain, Molecular Systems Biology 8:613, 2012.
- , A Reaction-Diffusion Mechanism Influences Cell Lineage Progression as a Basis for Formation, Regeneration, and Stability of Intestinal Crypts, BMC Systems Biology 6:93, 2012.
- , Simultaneous Prediction of Morphologies of a Critical Nucleus and an Equilibrium Precipitate in Solids, Commun. Comput. Phys., 7, 674-682, 2010.
- , Incorporating Non-classical Nuclei in Phase-field Simulations, Scripta Materialia, 63, 8-11, 2010.
- , Diffuse-Interface Approach to Predicting Morphologies of Critical Nucleus and Equilibrium Structure for Cubic to Tetragonal Transformations, J. Comput. Phys., 229, 6574-6584, 2010.
- , A constrained string method and its numerical analysis, Commun. Math. Sci., 7, 1039-1051, 2009.
- , Mathematical and Numerical Aspects of Phase-field Approach to Critical Morphology in Solids, Journal of Scientific Computing, 37, 89-102, 2008.
- , Diffuse-Interface Description of Strain-Dominated Morphology of Critical Nuclei in Phase Transformations, Acta Materialia, 56, 3568-3576, 2008.
- Highlight, Morphology of critical nuclei in solid state phase transformations, Physical Review Letters, 98, No.25, 265703, 2007.
Software 软件
Book 著作
- , 生物数学建模 , 高等教育出版社 (2025)